99.9% minN, N-dimethylformamide (DMF), pure dimethylformamide manufacturer, dimethyl substitution,
Dimethylformamide (DMF) is a colorless and transparent liquid that can be miscible with water and most organic solvents. Pure dimethylformamide has a special odor, while industrial-grade or deteriorated dimethylformamide has a fishy smell because it contains impurities of dimethylamine. The origin of the name is because it is a dimethyl substitution of formamide (formic acid amide), and both methyl groups are located on the N (nitrogen) atom. It is a commonly used solvent for chemical reactions. As a high-boiling polar (hydrophilic) aprotic solvent, it can promote the SN₂ reaction mechanism. Dimethylformamide is manufactured using methyl formate and dimethylamine. Dimethylformamide is unstable in the environment of strong bases such as sodium hydroxide or strong acids such as hydrochloric acid or sulfuric acid (especially at high temperatures), and hydrolyzed to formic acid and dimethylamine, the equation of which is HCON (CH₃) ₂ + H₂O → (CH₃) ₂NH + HCOOH.
The preliminary list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization, dimethylformamide is in the list of carcinogens of category 2A。
Package：190Kg/Drum or Isotank
Application: Pharmaceutical Intermediates,Agrochemical Intermediates etc.
Place of Origin:China(Mainland)
Port of Loading:Shanghai or Qingdao
Terms of Payment: TT、LC、DP
Delivery time: In stock
The main uses of N, N-dimethylformamide (DMF):
[Use 1] Used as analytical reagent and solvent for vinyl resin and acetylene.
[Use 2] It is an excellent organic solvent. It is used as a solvent for polyurethane, polyacrylonitrile, and polyvinyl chloride. It is also used as a raw material for extractants, medicines, and pesticides.
[Use 3] Dimethylformamide is not only a chemical material with extremely wide application, but also an excellent solvent with wide application. It can be used for wet spinning of polyacrylonitrile fiber and other synthetic fibers, and for the synthesis of polyurethane; it can be used for plastic film; it can also be used as a paint remover for removing paint; it can also dissolve some low-solubility pigments, making the pigments with dye specialty. Dimethylformamide can be used for aromatic hydrocarbon extraction and for the separation and recovery of butadiene from the C4 fraction and isoprene from the C5 fraction, and it can also be used as an effective reagent for separating non-hydrocarbon components from paraffin . It has good selectivity to the solubility of isophthalic acid and terephthalic acid: isophthalic acid is more soluble in dimethylformamide than terephthalic acid, solvent extraction in dimethylformamide or Partially crystallized, the two can be separated. In the petrochemical industry, dimethylformamide can be used as a gas absorbent to separate and purify gases. In organic reactions, dimethylformamide is not only widely used as a solvent for the reaction, but also an important intermediate in organic synthesis. It can be used in the pesticide industry to produce acetamiprid; in the pharmaceutical industry, it can be used to synthesize sulfadiazine, doxycycline, cortisone, vitamin B6, iodine, carbendazim, thiuracil, N-formyl sarcoma, anti-tumor L-amino acid, methoxyaryl mustard, benzalkonium mustard, cyclohexyl nitrosourea, furosemide, hemostatic acid, bemetamethasone, megestrol, cholevitamin, chlorpheniramine and so on. Dimethylformamide has a catalytic effect in the reactions of hydrogenation, dehydrogenation, dehydration and dehydrohalogenation, which reduces the reaction temperature and improves the purity of the product.
[Use 4] Reagents for non-aqueous solution titration, solvents for vinyl resin and acetylene, organic synthesis, photometric determination, gas chromatographic fixatives (maximum use temperature 50 ℃, solvent is methanol), separation and analysis of C2-C5 hydrocarbons, and can separate positive , Isobutene-  and cis and trans-butene- . Pesticide residue analysis. Organic Synthesis. Peptide synthesis. For the photographic industry.
N, N-dimethylformamide (DMF) fire protection measures:
Use water spray, dry powder, alcohol-resistant foam, carbon dioxide and sand to extinguish the fire. Use water to keep the container cool in the fire.
Storage and transportation instructions
Packing mark: flammable liquid. Packing method: (Ⅲ) category. The outer glass box of the glass bottle is lined with non-combustible materials or aluminum barrels or galvanized iron barrels. Storage and transportation conditions: Store in a cool, ventilated warehouse. Keep away from fire and heat. Separated from halogenated hydrocarbons, nitrates and nitrates, methane diisocyanate, carbon tetrachloride, phosphorus trioxide, triethylaluminum, oxidants and acids. Lightly load and unload during handling to keep the package intact.
First cut off all sources of ignition and wear gas masks and gloves. Rinse with water and dilute the sewage into the wastewater system.
It is mainly used as a solvent for extracting acetylene and manufacturing polyacrylonitrile fiber. It is also used in industries such as organic synthesis, dyes, pharmaceuticals, petroleum refining and resins. In the above work positions, it can be poisoned by exposure to DMF steam. Most of the causes of acute poisoning are due to production failure, equipment leakage, or failure to take effective protective measures when overhauling the equipment, and a large amount of exposure to poison. Poisoning is often caused by coexistence of inhalation and skin absorption, and mainly skin absorption.
Other cases of poisoning are rare, but there are cases of severe poisoning caused by oral administration and enema of this product as a drug for the treatment of ulcerative colitis.
N, N-dimethylformamide (DMF) emergency treatment method:
Accidental release measures
Quickly evacuate personnel from the leaked contaminated area to a safe area and isolate them, strictly restricting access. Cut off the ignition source. It is recommended that emergency personnel wear self-contained positive pressure respirator and fire protective clothing. Cut off the source of the leak as much as possible. Prevent entry into restricted spaces such as sewers and flood ditches.
Small amount of leakage: use sand or other non-combustible materials to absorb or absorb. It can also be rinsed with a large amount of water, diluted with washing water and put into the waste water system.
Large amount of leakage: constructing dikes or digging pits to contain; covering with foam to reduce steam hazards. Use an explosion-proof pump to transfer to tank truck or special collector, and recycle or transport to waste disposal site for disposal.
Waste disposal method: use incineration method. After the waste material is dissolved in a flammable solvent, it is incinerated. The gas discharged from the incinerator should pass through the alkali scrubber to remove harmful components, and recover N, N-dimethylformamide from the clean solvent in the fiber sedimentation tank and the polyvinyl chloride reactor.
Respiratory protection: When the concentration in the air exceeds the standard, wear a filtering gas mask (half mask).
Eye protection: Wear chemical safety glasses.
Body protection: Wear chemical protective clothing.
Hand protection: wear rubber gloves.
Others: Smoking is strictly prohibited at the work site. After work, take a shower and change clothes.
Skin contact: Remove contaminated clothing and rinse with plenty of running water for at least 15 minutes. See a doctor.
Eye contact: Lift the eyelid immediately and rinse thoroughly with plenty of running water or saline for at least 15 minutes. See a doctor.
Inhalation: Quickly leave the scene to a place with fresh air (upwind). Keep the airway clear. If breathing is difficult, give oxygen. If breathing stops, give artificial respiration immediately. See a doctor.
Ingestion: Drink plenty of warm water, induce vomiting, and seek medical attention.
Fire extinguishing method: Fire extinguishing agent: mist water, alcohol-resistant foam, dry powder, carbon dioxide, sand. As far as possible, move the container from the fire to an open place. Use water spray to keep the fire field container cool until the end of the fire extinguishment.